Description

(Sar1, Thr8)-Angiotensin II Acetate Hydrate is a synthetic, biologically active peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, featuring specific amino acid substitutions at positions 1 and 8. This modification is designed to enhance receptor binding affinity and metabolic stability, making it a critical tool for cardiovascular and renal system research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in studying hypertension, heart failure, and related signaling pathways.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of the renin-angiotensin system (RAS), blood pressure regulation, and vascular smooth muscle contraction.
• Receptor Binding Assays: Serves as a high-affinity ligand for characterizing and quantifying Angiotensin II type 1 (AT1) and type 2 (AT2) receptors.
• Biochemical Pathway Analysis: Employed to investigate intracellular signaling cascades, including calcium mobilization and protein kinase activation, triggered by angiotensin receptor stimulation.
• Drug Discovery & Development: Acts as a key molecular tool for screening and validating novel antihypertensive drug candidates and receptor antagonists.
• In Vitro & Ex Vivo Studies: Applied in organ bath experiments and cell-based assays to model cardiovascular diseases and assess therapeutic interventions.

Basic Information

Product Name	(Sar1, Thr8)-Angiotensin II Acetate Hydrate
CAS No.	67724-26-9
Molecular Formula	C49H69N13O11 • xC2H4O2 • yH2O
Molecular Weight	~1040.2 (Anhydrous free base)
Synonyms	[Sar1, Thr8]-Angiotensin II; Sar-Thr8-Angiotensin II; Angiotensin II (1-8) (Sar1, Thr8); H-Sar-Arg-Val-Tyr-Ile-His-Pro-Thr-OH; (Sar1,Thr8)-All; Asp-Arg-Val-Tyr-Ile-His-Pro-Thr (1-Sarcosine, 8-Threonine); ATII Analog (Sar1, Thr8)
EINECS	Contact for details

Quality Control

Our (Sar1, Thr8)-Angiotensin II Acetate Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, acetate and water content, and residual solvents are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Water Content (KF)	≤ 10.0%
Acetate Content (IC)	5.0% - 12.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.