Description

n-(2-Iodoethyl)Trifluoro-Acetamide is a specialized organoiodine building block featuring a reactive iodoethyl group and a trifluoroacetamide moiety. This compound is valued for its utility as a versatile intermediate in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, where it serves as a key precursor for introducing functionalized ethylamine chains or for further cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated ethylamine side chains.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate fluorinated amide structures.
• Medicinal Chemistry: Serves as a versatile scaffold for creating compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: The iodine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions, such as Heck, Sonogashira, or Suzuki reactions.
• Bioconjugation & Labeling: Potential use in modifying biomolecules or creating fluorescent or radioactive probes due to the reactive iodoethyl handle.
• Material Science Precursor: Can be utilized in the synthesis of specialized polymers or organic electronic materials that benefit from fluorine incorporation.

Basic Information

Product Name	n-(2-Iodoethyl)Trifluoro-Acetamide
CAS No.	67680-56-2
Molecular Formula	C4H5F3INO
Molecular Weight	266.99 g/mol
Synonyms	2-Iodo-N-(2,2,2-trifluoroacetyl)ethanamine; N-(2-Iodoethyl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-(2-iodoethyl)acetamide; TFIA; Iodoethyl Trifluoroacetamide; Ethanamine, 2-iodo-N-(2,2,2-trifluoroacetyl)-; Trifluoroacetamide, N-(2-iodoethyl)-
EINECS	Contact for details

Quality Control

Our n-(2-Iodoethyl)Trifluoro-Acetamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.