Description

H-Dl-Trp-Nh2 Hcl CAS NO 67607-61-8 is a protected derivative of the essential amino acid tryptophan, specifically the hydrochloride salt of Nα-Benzyloxycarbonyl-DL-tryptophanamide. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, offering a protected amine group for controlled peptide coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new therapeutic peptides and peptidomimetic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected tryptophan derivative to prevent side reactions.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway investigations involving tryptophan.
• Asymmetric Synthesis: Employed in the preparation of non-natural amino acids and complex organic molecules requiring specific stereochemistry.
• API Development: An important intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	H-Dl-Trp-Nh2 Hcl
CAS No.	67607-61-8
Molecular Formula	C19H20N3O3 • HCl
Molecular Weight	375.84 g/mol (Free base: 338.38 g/mol)
Synonyms	Nα-Carbobenzoxy-DL-tryptophanamide hydrochloride; Z-DL-Trp-NH2 • HCl; N-Cbz-DL-tryptophanamide hydrochloride; Benzyloxycarbonyl-DL-tryptophanamide hydrochloride; (RS)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanamide hydrochloride; DL-N-Carbobenzoxytryptophanamide hydrochloride; Cbz-DL-Trp-NH2 • HCl; H-DL-Trp-NH2 • HCl (Cbz-protected)
EINECS	Contact for details

Quality Control

Our H-Dl-Trp-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting research and pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) specifying purity, chiral purity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	DL-mixture (approx. 50:50 ratio)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.