Description

4-Azidopuromycin is a specialized puromycin derivative, a critical biochemical tool for advanced research applications. Its unique azide functional group enables efficient bioorthogonal conjugation, making it indispensable for studying protein synthesis and cellular processes. This compound is primarily utilized by researchers and developers in the fields of chemical biology, proteomics, and pharmaceutical discovery.

Application

• Chemical Biology Research: As a click chemistry reagent for labeling and tracking newly synthesized proteins via bioorthogonal reactions.
• Proteomics Studies: For pulse-chase experiments to analyze protein synthesis rates, degradation, and turnover in live cells.
• Antibiotic Mechanism Investigation: Serves as a molecular probe to study the function of the ribosome and the mechanisms of translation inhibitors.
• Drug Discovery Platforms: Used in the development of high-throughput screening assays for identifying novel antimicrobial agents.
• Bioconjugation: Facilitates the site-specific attachment of fluorophores, affinity tags, or other molecules to biomolecules for imaging and purification.
• Academic & Industrial R&D: A key reagent in foundational and applied research within university laboratories and biotech/pharma R&D departments.

Basic Information

Product Name	4-Azidopuromycin
CAS No.	67607-41-4
Molecular Formula	C22H29N7O5
Molecular Weight	471.51 g/mol
Synonyms	Puromycin, 4-azido-; 4-Azido-3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine; 4-Azido-N6,N6-dimethyl-3'-deoxy-3'-(p-methoxy-L-phenylalanylamino)adenosine; 4-Azido-3'-deoxy-N6,N6-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine; Azidopuromycin
EINECS	Contact for details

Quality Control

Our 4-Azidopuromycin is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in academic and industrial research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a dry, cool, and well-ventilated area. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.