Description

2'-Hydroxy-5'-(Trifluoromethyl)Acetophenone is a versatile trifluoromethylated aromatic ketone that serves as a critical synthetic intermediate. Its value lies in the unique combination of the acetophenone core, a phenolic hydroxyl group, and the electron-withdrawing trifluoromethyl moiety, which imparts desirable properties to final compounds. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients, particularly where enhanced metabolic stability and lipophilicity are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers with tailored optical and electronic properties.
• Fluorine Chemistry Studies: An important substrate for investigating the influence of fluorine atoms on chemical reactivity and physical characteristics in organic molecules.

Basic Information

Item	Details
Product Name	2'-Hydroxy-5'-(Trifluoromethyl)Acetophenone
CAS No.	67589-15-5
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-(2-Hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one; 2'-Hydroxy-α,α,α-trifluoro-5'-methylacetophenone; 2-Acetyl-4-(trifluoromethyl)phenol; 5-(Trifluoromethyl)-2-hydroxyacetophenone; 2-Hydroxy-5-trifluoromethylacetophenone; 1-[2-Hydroxy-5-(trifluoromethyl)phenyl]ethanone; HTA; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2'-Hydroxy-5'-(Trifluoromethyl)Acetophenone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.