Description

Normorphine-3-Glucuronide is a crucial glucuronide metabolite of normorphine, a key intermediate in the study of opioid metabolism. This high-purity reference standard is essential for accurate analytical quantification and metabolic pathway research in pharmaceutical development. It is primarily utilized by research institutions, forensic laboratories, and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) studies, toxicology screening, and the development of advanced bioanalytical methods.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative analysis of opioid metabolites in biological matrices using LC-MS/MS and HPLC.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to understand the metabolic fate, clearance, and glucuronidation pathways of normorphine and related opioids.
• Forensic Toxicology: Used as a calibrant or control in confirmatory testing for opioid use, supporting legal and workplace testing programs.
• Biomarker Research: Employed in clinical research to investigate correlations between metabolite levels, dosage, and physiological effects.
• Enzyme Activity Assays: Acts as a specific substrate for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes, particularly UGT2B7.
• Method Development & Validation: Essential for developing, optimizing, and validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Normorphine-3-Glucuronide
CAS No.	67583-64-6
Molecular Formula	C23H27NO9
Molecular Weight	461.46 g/mol
Synonyms	Normorphine 3-β-D-Glucuronide; 3-Normorphine Glucuronide; Normorphine-3-β-D-Glucopyranosiduronic Acid; Normorphine Glucuronide; N-Desmethylmorphine-3-Glucuronide; 7,8-Didehydro-4,5α-epoxy-3-hydroxy-17-methylmorphinan-6-one 3-Glucuronide (related); Opioid Metabolite Reference Standard
EINECS	Contact for details

Quality Control

Every batch of Normorphine-3-Glucuronide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) with batch-specific data from advanced techniques like HPLC, LC-MS, and NMR to confirm identity, purity, and strength. Our quality commitment ensures the material meets the exacting standards required for pharmaceutical research and regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.