Description

Edaravone Glucuronide is a major, pharmacologically relevant metabolite of the neuroprotective agent Edaravone. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of analytical chemistry and drug metabolism studies. It serves as a key reference standard for quantifying Edaravone and its metabolites in biological matrices, ensuring accurate pharmacokinetic and bioanalytical data. Researchers and quality control laboratories in the pharmaceutical and biotechnology industries rely on this high-purity standard to support drug development, regulatory submissions, and clinical studies.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of Edaravone and its metabolites in pharmacokinetic studies.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for drug metabolism and pharmacokinetics (DMPK) research.
• Metabolite Identification & Profiling: Used as an authentic standard to identify and characterize Edaravone metabolites in in vitro and in vivo studies.
• Quality Control & Assurance: Critical for the quality control of Edaravone-based drug products and for ensuring batch-to-batch consistency in manufacturing.
• Regulatory Compliance & Submission: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive data on drug metabolism for new drug applications (NDAs).
• Clinical Research: Enables precise monitoring of Edaravone levels in patient plasma or serum during clinical trials for conditions like Amyotrophic Lateral Sclerosis (ALS) and ischemic stroke.

Basic Information

Product Name	Edaravone Glucuronide
CAS No.	67566-02-3
Molecular Formula	C15H16N2O9
Molecular Weight	368.30 g/mol
Synonyms	3-Methyl-1-phenyl-2-pyrazolin-5-one Glucuronide; 1-Phenyl-3-methyl-5-pyrazolone Glucuronide; MCI-186 Glucuronide; Radicava Glucuronide; Edaravone β-D-Glucuronide; Edaravone Glucuronide Conjugate; 5-Pyrazolone, 1-phenyl-3-methyl-, β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Edaravone Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and all relevant analytical data to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.