Description

Vanoxerine Dihydrochloride is a high-purity, small molecule compound of significant interest in pharmaceutical research and development. It serves as a potent and selective dopamine reuptake inhibitor, making it a valuable pharmacological tool for studying neurological pathways. This compound is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in neuroscience, neuropharmacology, and drug discovery programs.

Application

• Neuroscience Research: Used as a selective pharmacological agent to study dopamine transporter (DAT) function and dopaminergic signaling in the central nervous system.
• Drug Discovery & Development: Serves as a reference standard, lead compound, or biochemical tool in the development of novel therapeutics for neurological and psychiatric disorders.
• In Vitro & In Vivo Studies: Employed in cellular assays and animal models to investigate mechanisms related to addiction, depression, Parkinson's disease, and attention deficit hyperactivity disorder (ADHD).
• Biochemical Screening: Acts as a control or inhibitor in high-throughput screening (HTS) assays targeting monoamine transporters.
• Academic Research: Utilized in university and institutional labs for fundamental research into neurotransmitter dynamics and receptor interactions.
• Reference Standard: Provides a certified material for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	Vanoxerine Dihydrochloride
CAS No.	67469-78-7
Molecular Formula	C24H28N2O3 · 2HCl
Molecular Weight	473.41 g/mol (for dihydrochloride salt)
Synonyms	GBR-12909 Dihydrochloride; 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine Dihydrochloride; GBR 12909 dihydrochloride; Vanoxerine 2HCl; Dopamine Reuptake Inhibitor GBR-12909; GBR12909 2HCl
EINECS	Contact for details

Quality Control

Our Vanoxerine Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.