Description

Dimethyl (2S)-2-(Phenylmethoxycarbonylamino)Pentanedioate is a high-purity chiral building block and protected amino acid derivative. This compound is critical for the synthesis of complex peptides and pharmaceutical intermediates, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing new active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and protease inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected glutamic acid residue with a specific (S) configuration.
• Protecting Group Strategy: The Cbz (carboxybenzyl) group protects the amine functionality, allowing for selective reactions at other sites on the molecule during complex syntheses.
• Bioconjugation: Serves as a precursor for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugation platforms.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	Dimethyl (2S)-2-(Phenylmethoxycarbonylamino)Pentanedioate
CAS No.	67436-17-3
Molecular Formula	C15H19NO6
Molecular Weight	309.32 g/mol
Synonyms	Dimethyl L-2-[(Benzyloxycarbonyl)amino]pentanedioate; (S)-2-((Benzyloxycarbonyl)amino)pentanedioic Acid Dimethyl Ester; Cbz-L-Glu(OMe)-OMe; N-Carbobenzyloxy-L-glutamic Acid α-Methyl Ester γ-Methyl Ester; N-Cbz-L-glutamic Acid Dimethyl Ester; Z-L-Glu(OMe)-OMe; (2S)-2-{[(Benzyloxy)carbonyl]amino}pentanedioic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our Dimethyl (2S)-2-(Phenylmethoxycarbonylamino)Pentanedioate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.