Description

(S)-n-Boc-6-Fluorotryptophan CAS NO 67308-25-2 is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a fluorine substituent on the indole ring. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling advanced research and development in medicinal chemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in oncology and CNS disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a fluorinated tryptophan analog into peptide sequences.
• Proteomics Research: Serves as a building block for creating labeled or modified peptides for mass spectrometry and biochemical assay development.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing fluorine atoms to modulate the bioavailability and metabolic stability of lead compounds.
• Bioconjugation: The Boc-protected amine provides a handle for selective deprotection and further functionalization in bioconjugate and probe synthesis.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	(S)-n-Boc-6-Fluorotryptophan
CAS No.	67308-25-2
Molecular Formula	C₁₈H₂₃FN₂O₄
Molecular Weight	350.39 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(6-fluoro-1H-indol-3-yl)propanoic acid; Boc-6-F-DL-Trp-OH; N-Boc-6-fluoro-L-tryptophan; tert-Butyl (S)-(1-(6-fluoro-1H-indol-3-yl)-3-carboxy-1-oxopropan-2-yl)carbamate; 6-Fluoro-L-tryptophan, N-Boc-; (S)-3-(6-Fluoro-1H-indol-3-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid; Fmoc-6-F-Trp(Boc)-OH (related protected form); BOC-6F-TRP-OH
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-6-Fluorotryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.