Description

4-Hydroxyifosfamide is a key metabolite and active intermediate of the alkylating antineoplastic agent ifosfamide. This compound is of significant interest in pharmaceutical research and development, particularly in the study of drug metabolism, mechanism of action, and the synthesis of related therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery, metabolite profiling, and the production of high-purity reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for analytical method development and validation in pharmacokinetic and bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used as an authentic standard to identify and quantify the active metabolite in biological matrices during preclinical and clinical research on ifosfamide.
• Oncology Drug Development: Acts as a key intermediate in the research and synthesis of novel ifosfamide analogs or prodrugs aimed at improving therapeutic efficacy and reducing side effects.
• Biochemical Research: Employed in studies investigating the specific mechanisms of DNA alkylation and cross-linking by activated ifosfamide metabolites.
• Quality Control Testing: Essential for the identity and purity testing of ifosfamide active pharmaceutical ingredient (API) and related formulations in GMP environments.

Basic Information

Product Name	4-Hydroxyifosfamide
CAS No.	67292-64-2
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	4-Hydroxyifosfamide; Ifosfamide 4-Hydroxy Metabolite; NSC-351358; 3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 4-oxide; 4-Hydroxy-Ifosfamide; Hydroxyifosfamide; Ifosfamide Metabolite
EINECS	Contact for details

Quality Control

Our 4-Hydroxyifosfamide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic methods. We support compliance with relevant guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.