Description

n-(3-Methylcarbamoyl-5-Propionylamino-2,4,6-Triiodobenzoyl)Glycine is a high-purity, triiodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. This compound is critical for ensuring the quality and efficacy of final pharmaceutical formulations, providing the essential iodine content required for effective radiopacity. It is essential for manufacturers in the pharmaceutical and diagnostic imaging industries who require reliable, high-grade raw materials for producing non-ionic, low-osmolar contrast agents.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of non-ionic X-ray contrast media such as Iopromide, Ioversol, and Iopamidol.
• Diagnostic Imaging Agent Synthesis: Serves as a precursor for creating modern, low-osmolar contrast agents used in computed tomography (CT), angiography, and urography.
• Research & Development: Utilized in pharmaceutical R&D for developing new iodinated contrast agents with improved safety profiles and pharmacokinetics.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing of specialized triiodobenzene derivatives for medical applications.
• Quality Control Reference Standard: Can be supplied as a high-purity reference material for analytical method development and quality assurance testing in pharmaceutical production.

Basic Information

Product Name	n-(3-Methylcarbamoyl-5-Propionylamino-2,4,6-Triiodobenzoyl)Glycine
CAS No.	67227-37-6
Molecular Formula	C14H14I3N3O5
Molecular Weight	704.99 g/mol
Synonyms	Glycine, N-[3-[(methylamino)carbonyl]-5-[(1-oxopropyl)amino]-2,4,6-triiodobenzoyl]-; 5-Acetylamino-N-methylisophthalamic acid, 2,4,6-triiodo-3-(carboxymethylcarbamoyl)-; Iopromide intermediate; Ioversol impurity C; Iopamidol related compound; 2,4,6-Triiodo-3-(N-methylcarbamoyl)-5-propionamido-N-carboxymethylbenzamide; 5-Propionamido-2,4,6-triiodo-N-methylisophthalamic acid N-carboxymethylamide
EINECS	Contact for details

Quality Control

Our n-(3-Methylcarbamoyl-5-Propionylamino-2,4,6-Triiodobenzoyl)Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing compliance with agreed specifications. We support audits and can supply material suitable for use in GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.