Description

n-[3-(Methoxyacetylamino)-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine is a high-purity, triiodinated organic compound primarily used as a key intermediate in the synthesis of X-ray contrast media. This compound matters because it provides the essential iodine atoms required for effective radiopacity in diagnostic imaging agents, ensuring high-quality visualization of internal body structures. Pharmaceutical manufacturers and advanced chemical synthesis facilities need this intermediate for producing non-ionic, low-osmolar contrast agents, which are critical for patient safety and diagnostic accuracy in procedures like angiography, urography, and computed tomography (CT) scans.

Application

• Primary Intermediate for X-ray Contrast Media: Serves as the core building block in the synthesis of modern, non-ionic iodinated contrast agents such as Iopamidol, Ioversol, and Iopromide.
• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step organic synthesis processes under controlled GMP environments to ensure final drug product purity.
• Research & Development: Employed in academic and industrial R&D for developing new generations of contrast media with improved safety profiles and pharmacokinetics.
• Diagnostic Imaging Agent Production: Integral to manufacturing final formulated products used in hospitals and diagnostic imaging centers worldwide.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control testing in pharmaceutical labs.

Basic Information

Product Name	n-[3-(Methoxyacetylamino)-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine
CAS No.	67227-36-5
Molecular Formula	C14H14I3N3O6
Molecular Weight	744.99 g/mol
Synonyms	5-Acetamido-N-methyl-2,4,6-triiodoisophthalamic acid N-(2-methoxyacetyl) derivative; Glycine, N-[3-[(2-methoxyacetyl)amino]-5-[(methylamino)carbonyl]-2,4,6-triiodobenzoyl]-; Iopamidol Intermediate; Ioversol Related Compound; Iopromide Intermediate; Non-ionic Contrast Media Intermediate; 2,4,6-Triiodo-3-(methoxyacetylamino)-5-(N-methylcarbamoyl)benzoylglycine
EINECS	Contact for details

Quality Control

Our n-[3-(Methoxyacetylamino)-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine is manufactured under strict quality management systems, with a focus on meeting the stringent requirements for pharmaceutical intermediates. Each batch undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, residual solvents, and heavy metals are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) or customer specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Iodine Content	50.5% - 51.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.