Description

n-[3-[(Hydroxyacetyl)Amino]-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine is a high-purity, triiodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. This compound is critical for ensuring the safety and efficacy of final pharmaceutical formulations by providing a controlled, high-quality building block. It is essential for manufacturers in the pharmaceutical and diagnostic imaging industries who require reliable, specification-grade raw materials for producing non-ionic, low-osmolar contrast agents.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of non-ionic X-ray contrast media such as Iopamidol, Ioversol, and Iopromide.
• Diagnostic Imaging Agent Synthesis: Serves as a precursor for iodinated compounds used in computed tomography (CT), angiography, and urography.
• Research & Development: Used in academic and industrial R&D for developing new contrast agents with improved safety profiles and imaging characteristics.
• Fine Chemical Production: Employed in multi-step organic synthesis for creating complex, high-value iodinated aromatic molecules.
• GMP Manufacturing: Supplied as a qualified starting material for active pharmaceutical ingredient (API) production under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	n-[3-[(Hydroxyacetyl)Amino]-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine
CAS No.	67227-35-4
Molecular Formula	C13H12I3N3O6
Molecular Weight	674.96 g/mol
Synonyms	5-Acetamido-N-methyl-2,4,6-triiodoisophthalamic acid; Glycine, N-[3-[(hydroxyacetyl)amino]-5-[(methylamino)carbonyl]-2,4,6-triiodobenzoyl]-; Iopamidol Intermediate; Ioversol Impurity; Iopromide Related Compound; 5-Acetamido-2,4,6-triiodo-N-methylisophthalamic Acid; N-(3-Acetamido-2,4,6-triiodo-5-(N-methylcarbamoyl)benzoyl)glycine
EINECS	Contact for details

Quality Control

Our n-[3-[(Hydroxyacetyl)Amino]-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, to ensure it meets exacting standards suitable for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we can support compliance with ICH Q7 guidelines and customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.