Description

n-[3-(Acetylamino)-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine is a high-purity, triiodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. This compound matters for its critical role in producing safe and effective diagnostic agents, enabling clear medical imaging. It is essential for pharmaceutical manufacturers and research institutions focused on developing and producing non-ionic, low-osmolar contrast agents for angiography, urography, and computed tomography (CT) scans.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of non-ionic X-ray contrast media such as Iopamidol, Ioversol, and Iomeprol.
• Contrast Agent Manufacturing: Serves in the production chain for agents used in diagnostic procedures including cerebral, coronary, and peripheral angiography.
• Medical Imaging Research: Utilized in R&D for developing next-generation iodinated contrast agents with improved safety and imaging profiles.
• Radiopharmaceutical Synthesis: Potential use as a precursor in the development of specialized diagnostic imaging compounds.
• Quality Control Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality assurance in pharmaceutical production.

Basic Information

Product Name	n-[3-(Acetylamino)-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine
CAS No.	67227-34-3
Molecular Formula	C13H12I3N3O5
Molecular Weight	662.96 g/mol
Synonyms	5-Acetamido-N-methyl-2,4,6-triiodoisophthalamic acid N-glycine derivative; Iopamidol Intermediate; Ioversol Intermediate; 2,4,6-Triiodo-3-acetamido-5-[(methylamino)carbonyl]-N-(carboxymethyl)benzamide; Glycine, N-[3-(acetylamino)-5-[(methylamino)carbonyl]-2,4,6-triiodobenzoyl]-; 5-Acetamido-2,4,6-triiodo-N-methylisophthalamic acid glycine amide; BM 203-055 (developmental code); Contrast Media Intermediate BP-1.
EINECS	Contact for details

Quality Control

Our n-[3-(Acetylamino)-5-Methylaminocarbonyl-2,4,6-Triiodobenzoyl]Glycine is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Quality assurance includes rigorous testing to meet specifications for identity, purity, and impurity profiles, aligning with ICH Q7 guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from HPLC, IR, and residual solvent analysis to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.