Description

Chloroacetyl-Dl-Serine is a versatile chiral amino acid derivative, primarily recognized as a key synthetic intermediate in the production of complex organic molecules. Its bifunctional nature, featuring both a reactive chloroacetyl group and a serine backbone, makes it invaluable for constructing peptide mimetics and other pharmacologically active structures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce serine-like motifs with further modification potential.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of serine protease inhibitors, antibiotic analogs, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate modified serine residues, enabling the study of structure-activity relationships.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides and plant growth regulators that target specific enzymatic pathways.
• Bioconjugation: The chloroacetyl group provides a handle for selective conjugation with thiol-containing molecules, useful in creating antibody-drug conjugates (ADCs) or probe molecules.
• Chemical Biology Tool: Employed in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Custom Synthesis: A starting material for contract research organizations (CROs) and fine chemical manufacturers producing custom compounds for client projects.

Basic Information

Product Name	Chloroacetyl-Dl-Serine
CAS No.	67206-28-4
Molecular Formula	C5H8ClNO4
Molecular Weight	181.57 g/mol
Synonyms	2-Chloro-N-(1-carboxy-2-hydroxyethyl)acetamide; DL-2-Chloroacetamido-3-hydroxypropanoic acid; N-Chloroacetyldl-serine; Chloroacetylserine; (RS)-2-(2-Chloroacetamido)-3-hydroxypropanoic acid; Serine, N-chloroacetyl-, dl-; Acetamide, 2-chloro-N-(1-carboxy-2-hydroxyethyl)-
EINECS	Contact for details

Quality Control

Our Chloroacetyl-Dl-Serine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.