Description

Clonidine-D4 Hcl (Imidazoline-4,4,5,5-D4) is a high-purity, deuterium-labeled internal standard used for precise quantitative analysis. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in sensitive analytical methods, particularly liquid chromatography-mass spectrometry (LC-MS). It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities for method development, validation, and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of Clonidine in complex biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Method Development and Validation: Serves as a reference standard to establish and validate robust, GLP-compliant analytical methods.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to understand the metabolic pathways of Clonidine.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification of active pharmaceutical ingredients (APIs).
• Forensic and Doping Control Analysis: Provides definitive identification and quantification in forensic toxicology and anti-doping programs.

Basic Information

Item	Detail
Product Name	Clonidine-D4 Hcl (Imidazoline-4,4,5,5-D4)
CAS No.	67151-02-4
Molecular Formula	C9H5D4Cl2N3·HCl
Molecular Weight	273.60 g/mol
Synonyms	Clonidine-d4 hydrochloride; 2,6-Dichloro-N-(2-imidazolidinylidene-4,4,5,5-d4)benzenamine hydrochloride; 2-[(2,6-Dichlorophenyl)imino]imidazolidine-4,4,5,5-d4 hydrochloride; Deuterated Clonidine HCl; Catapres-d4; [2H4]-Clonidine hydrochloride; ST 155-d4
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality systems to ensure the highest isotopic purity and chemical integrity. Each batch is fully characterized by NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically ≥98% D), chemical purity (≥95%), and analytical results. We support compliance with GMP/GLP guidelines for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.