Description

Eflornithine is a potent and selective irreversible inhibitor of ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis. This mechanism of action makes it a critical active pharmaceutical ingredient (API) for targeted therapeutic applications. It is primarily utilized by pharmaceutical manufacturers and research institutions developing treatments for conditions involving uncontrolled cellular proliferation.

Application

• Pharmaceutical API: Primary use as the active ingredient in topical formulations for the treatment of hirsutism (excessive facial hair growth in women).
• Oncology Research: Investigated for its antiproliferative effects in various cancer research models due to its role in inhibiting polyamine synthesis essential for cell growth.
• Parasitic Disease Treatment: Used in systemic formulations for the treatment of the second stage of African sleeping sickness (human African trypanosomiasis) caused by *Trypanosoma brucei gambiense*.
• Dermatological R&D: Serves as a key compound in research and development of new dermatological products targeting hair follicle activity.
• Biochemical Research: A vital tool in biochemical and pharmacological studies to understand polyamine metabolism and its cellular functions.

Basic Information

Product Name	Eflornithine
CAS No.	67037-37-0
Molecular Formula	C6H12F2N2O2
Molecular Weight	182.17 g/mol
Synonyms	DFMO; 2-(Difluoromethyl)ornithine; 2-(Difluoromethyl)-DL-ornithine; α-Difluoromethylornithine; Ornidyl; Eflornithine hydrochloride; (RS)-2-(Difluoromethyl)ornithine; DL-α-Difluoromethylornithine
EINECS	Contact for details

Quality Control

Our Eflornithine is manufactured under strict quality systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to current Good Manufacturing Practices (cGMP) and can supply material compliant with relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.