Description

1-(Bromomethyl)-4-(1,1,2,2-Tetrafluoroethoxy)Benzene is a high-value fluorinated aromatic building block, essential for introducing both a reactive benzyl bromide handle and a lipophilic, electron-withdrawing tetrafluoroethoxy group into target molecules. Its unique structure makes it a critical intermediate for advanced material science and pharmaceutical research, enabling the synthesis of complex compounds with tailored properties. This product is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty polymer industries.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic ether motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the tetrafluoroethoxy group enhances lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to functionalize polymers, introducing reactive sites for further cross-linking or to impart specific surface properties.
• Cross-Coupling Reactions: The benzyl bromide moiety participates in various metal-catalyzed coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Ligand & Catalyst Design: Useful for synthesizing specialized fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	1-(Bromomethyl)-4-(1,1,2,2-Tetrafluoroethoxy)Benzene
CAS No.	67033-41-4
Molecular Formula	C9H7BrF4O
Molecular Weight	287.05 g/mol
Synonyms	4-(1,1,2,2-Tetrafluoroethoxy)benzyl Bromide; p-(1,1,2,2-Tetrafluoroethoxy)benzyl Bromide; α-Bromo-4-(1,1,2,2-tetrafluoroethoxy)toluene; 1-Bromomethyl-4-(1,1,2,2-tetrafluoroethoxy)benzene; Benzene, 1-(bromomethyl)-4-(1,1,2,2-tetrafluoroethoxy)-; (4-(1,1,2,2-Tetrafluoroethoxy)phenyl)methyl Bromide
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-4-(1,1,2,2-Tetrafluoroethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.