Description

Hemoglobin Beth Israel CAS NO 67016-54-0 is a specific, naturally occurring variant of human hemoglobin, characterized by a point mutation that alters its oxygen-binding properties. This compound is of significant value in biochemical and clinical research for studying hemoglobinopathies and oxygen transport dynamics. It is primarily needed by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in hematology research, the development of biosensors, and the study of blood-related disorders.

Application

• Biochemical Research: Used as a reference standard in the study of hemoglobin structure-function relationships, oxygen affinity, and allosteric regulation.
• Clinical Diagnostics: Serves as a critical control material in the development and calibration of diagnostic assays for detecting abnormal hemoglobin variants.
• Pharmaceutical Development: Employed in preclinical studies investigating therapeutic approaches for sickle cell disease and other hemoglobin disorders.
• Hematology Studies: Essential for in-vitro experiments modeling blood physiology and pathology related to oxygen transport.
• Educational Reference: Used in advanced academic settings to teach concepts of molecular genetics, protein biochemistry, and hereditary diseases.
• Biosensor Calibration: Acts as a calibrant for optical sensors and analytical instruments designed to measure blood oxygen parameters.

Basic Information

Product Name	Hemoglobin Beth Israel
CAS No.	67016-54-0
Molecular Formula	C2952H4664N812O832S40Fe4 (for α2β2 tetramer)
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Beth Israel; Hemoglobin variant Beth Israel; Hemoglobin β-chain variant Beth Israel; HBB: c.316C>T; Hemoglobin with substitution β102(G4)Asn→Thr; Unstable hemoglobin Beth Israel; Hemoglobin, Beth Israel type; Contact for details on additional research codes.
EINECS	Contact for details

Quality Control

Our Hemoglobin Beth Israel is produced and handled under stringent conditions to ensure batch-to-batch consistency and reliability for research purposes. Each lot is characterized for identity and purity using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), spectral properties, and functional activity is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Aliquot into single-use vials after thawing to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Lyophilized powder
Identification (IR / HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Functional)	Contact for details
Solubility	Soluble in aqueous buffer
Protein Content (Biuret)	Contact for details
Endotoxin	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.