Description

21-o-Acetyl 6α-Hydroxy Cortisol is a synthetic steroid derivative and a key intermediate in the synthesis of more complex corticosteroid compounds. This high-purity intermediate is critical for pharmaceutical R&D and production, enabling precise chemical modifications to develop novel therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of steroidal drugs, anti-inflammatory agents, and metabolic regulators.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new steroidal drug candidates.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in metabolic pathway studies and as a tool compound to investigate glucocorticoid receptor interactions and enzyme inhibition.

Basic Information

Product Name	21-o-Acetyl 6α-Hydroxy Cortisol
CAS No.	67012-81-1
Molecular Formula	C23H32O7
Molecular Weight	420.50 g/mol
Synonyms	21-O-Acetyl-6α-hydroxycortisol; 6α-Hydroxycortisol 21-acetate; 11β,17α,21-Trihydroxy-6α-hydroxypregn-4-ene-3,20-dione 21-acetate; Cortisol, 21-acetate, 6α-hydroxy-; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-6-hydroxy-, 21-acetate, (6α,11β)-
EINECS	Contact for details

Quality Control

Our 21-o-Acetyl 6α-Hydroxy Cortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates and research chemicals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.