Description

Metkephamid is a synthetic peptide with the CAS registry number 66960-34-7, recognized for its role as a cholecystokinin (CCK) receptor antagonist. This compound is of significant interest in biochemical and pharmacological research for modulating gastrointestinal and central nervous system functions. It is primarily utilized by research institutions and pharmaceutical development laboratories investigating digestive disorders, satiety mechanisms, and potential therapeutic applications.

Application

• Biochemical Research: Used as a selective cholecystokinin (CCK) antagonist to study receptor binding, signal transduction pathways, and enzyme interactions in vitro.
• Pharmacological Studies: Employed in animal models to investigate the effects of CCK inhibition on pancreatic secretion, gastric emptying, and satiety.
• Neuroscience Research: Applied in studies exploring the role of CCK in anxiety, pain perception, and memory within the central nervous system.
• Drug Discovery & Development: Serves as a reference standard or lead compound in the development of novel therapeutics for gastrointestinal disorders and obesity.
• Academic & Institutional Labs: A key reagent for graduate and post-doctoral research projects focusing on peptide hormones and their antagonists.

Basic Information

Product Name	Metkephamid
CAS No.	66960-34-7
Molecular Formula	C42H56N10O10S
Molecular Weight	893.03 g/mol
Synonyms	Boc-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2; CCK-8 Antagonist; L-364,718 (related analog); Cholecystokinin Antagonist; [N-(tert-Butoxycarbonyl)-O-sulfo-L-tyrosyl]-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide; Boc-Tyr(SO3Na)-Met-Gly-Trp-Met-Asp-Phe-NH2; Metkephamid Acetate
EINECS	Contact for details

Quality Control

Our Metkephamid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and nuclear magnetic resonance (NMR) spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.