Description

Boc-n-Me-Met-Oh CAS NO 66959-86-2 is a protected amino acid derivative, specifically N-tert-Butoxycarbonyl-N-methyl-L-methionine. This compound is a crucial building block in the synthesis of complex peptides and peptidomimetics, where it introduces a methylated methionine residue with orthogonal protection. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and novel bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of N-methyl-methionine into peptide chains, enhancing metabolic stability and modulating physicochemical properties.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Serves as a precursor for creating non-natural peptide analogs with improved bioavailability and receptor selectivity.
• Bioconjugation: Can be employed in the synthesis of peptide tags or linkers for protein labeling and antibody-drug conjugate (ADC) development.
• Academic & Industrial R&D: A valuable reagent for synthetic chemistry and biochemistry research focused on protein structure-activity relationships.

Basic Information

Product Name	Boc-n-Me-Met-Oh
CAS No.	66959-86-2
Molecular Formula	C12H23NO5S
Molecular Weight	293.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N-methyl-L-methionine; Boc-N-methyl-L-methionine; Nα-Boc-Nα-methyl-L-methionine; (S)-2-((tert-Butoxycarbonyl)(methyl)amino)-4-(methylthio)butanoic acid; Boc-N-Me-Met-OH; N-Methyl-N-Boc-L-methionine; tert-Butyl (1-((S)-3-(methylthio)-1-oxo-1-(oxo)propyl)ethyl)carbamate
EINECS	Contact for details

Quality Control

Our Boc-n-Me-Met-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing specifications for purity, appearance, and specific rotation to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-20° to -25° (c=1 in DMF)
Chiral Purity	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.