Description

1-Epi-Calcitriol is a biologically significant analog of calcitriol, the active form of vitamin D3. This compound is a critical reference standard and intermediate in pharmaceutical research and development, particularly for studying vitamin D metabolism and receptor interactions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, well-characterized compounds for analytical and synthetic applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay validation of vitamin D analogs in drug development and manufacturing.
• Biochemical Research: Serves as a key tool in metabolic pathway studies, receptor binding assays, and pharmacological research related to calcium homeostasis and cell differentiation.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a crucial synthetic precursor in the multi-step production of advanced vitamin D-based therapeutics.
• Analytical Chemistry: Employed as a high-purity standard for method development and calibration in chromatographic techniques like HPLC and LC-MS.

Basic Information

Product Name	1-Epi-Calcitriol
CAS No.	66791-71-7
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1-Epicalcitriol; (1R,3S,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; 1-Epi-1,25-Dihydroxycholecalciferol; 1α,25-Dihydroxyvitamin D3 epimer; 1-Epi-1,25-Dihydroxyvitamin D3
EINECS	Contact for details

Quality Control

Our 1-Epi-Calcitriol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.