Description

4-Hydroxyetretinate is a significant metabolite and derivative of the retinoid class, known for its potent biological activity. This compound is crucial for advanced pharmaceutical research and development, particularly in the study of cell differentiation and proliferation pathways. It serves as a key intermediate and reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors requiring high-purity, well-characterized active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel retinoid-based therapeutics.
• Reference Standard: Used as a high-purity standard in analytical laboratories for method development, validation, and quality control (QC) of related pharmaceutical products.
• Biochemical Research: Employed in life science research to study the mechanisms of action, metabolism, and structure-activity relationships (SAR) of vitamin A derivatives.
• Dermatology R&D: Investigated for potential applications in the development of treatments for skin conditions, leveraging its retinoid activity.
• Metabolite Studies: Essential for pharmacokinetic and metabolic profiling studies of etretinate and related compounds.

Basic Information

Product Name	4-Hydroxyetretinate
CAS No.	66757-07-1
Molecular Formula	C23H30O3
Molecular Weight	354.49 g/mol
Synonyms	Etretin; Ro 10-9359/001; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid; 4-Hydroxyetretin; Etretinate Metabolite; Arotinoid Metabolite; TMMP Retinoic Acid Derivative
EINECS	Contact for details

Quality Control

Our 4-Hydroxyetretinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.