Description

Boc-Asu-Oh CAS NO 66713-87-9 is a protected amino acid derivative, specifically N-Boc-L-aspartic acid 4-tert-butyl ester, serving as a crucial building block in peptide synthesis. Its primary value lies in providing orthogonal protection for the side-chain carboxylic acid of aspartic acid, enabling precise and sequential peptide chain assembly. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides and protein-based drugs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, particularly those containing aspartic acid residues.
• Solution-Phase Peptide Synthesis: Used in classical coupling methodologies for constructing peptide fragments in solution.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and production of active pharmaceutical ingredients (APIs) for peptide therapeutics.
• Bioconjugation & Labeling: The protected carboxylic acid group can be selectively deprotected for subsequent conjugation with other molecules, such as fluorescent dyes or polymers.
• Chemical Biology Research: Employed in the synthesis of custom peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Process Development & Scale-Up: Supplied in consistent quality for process optimization and cGMP manufacturing of peptide-based drugs.

Basic Information

Item	Details
Product Name	Boc-Asu-Oh
CAS No.	66713-87-9
Molecular Formula	C13H23NO6
Molecular Weight	289.32 g/mol
Synonyms	N-Boc-L-aspartic acid 4-tert-butyl ester; (2S)-2-[(tert-Butoxycarbonyl)amino]butanedioic acid 4-tert-butyl ester; Boc-Asp(OtBu)-OH; Boc-L-Asp(OtBu)-OH; N-α-Boc-L-aspartic acid β-tert-butyl ester; tert-Butyl N-[(1S)-3-tert-butoxy-1,3-dioxopropyl]carbamate; Boc-Aspartic acid(OtBu); N-Boc-Asp(OtBu)-OH
EINECS	Contact for details

Quality Control

Our Boc-Asu-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical research and development. Each lot undergoes comprehensive analytical testing including HPLC for assay and chiral purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.