Description

1-(Hydroxymethyl)-5-Oxo-Dl-Proline is a versatile proline derivative characterized by a hydroxymethyl group and a ketone functionality on the pyrrolidine ring. This unique structure makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive compounds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, including protease inhibitors and other biologically active molecules.
• Peptide Chemistry: Used in the preparation of modified peptides and peptidomimetics to enhance stability, bioavailability, or biological activity.
• Agrochemical Research: Serves as a building block for developing new active ingredients with specific stereochemical requirements.
• Fine Chemical Synthesis: Employed in asymmetric synthesis and as a precursor for complex natural product analogs and specialty chemicals.
• Bioconjugation & Linker Chemistry: The reactive hydroxymethyl and carbonyl groups facilitate its use in creating chemical linkers for bioconjugation applications.

Basic Information

Product Name	1-(Hydroxymethyl)-5-Oxo-Dl-Proline
CAS No.	66702-19-0
Molecular Formula	C6H9NO4
Molecular Weight	159.14 g/mol
Synonyms	5-Oxo-1-pyrrolidinecarboxylic acid, hydroxymethyl-; DL-1-(Hydroxymethyl)-5-oxoproline; Hydroxymethyl-5-oxoproline; (RS)-1-(Hydroxymethyl)-5-oxopyrrolidine-2-carboxylic acid; 5-Oxo-1-(hydroxymethyl)proline; 1-Hydroxymethyl-5-oxoproline; Pyrrolidine-1-carboxylic acid, 5-oxo-, hydroxymethyl-
EINECS	Contact for details

Quality Control

Our 1-(Hydroxymethyl)-5-Oxo-Dl-Proline is produced under a stringent quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets exacting standards for research and industrial use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-Mixture (Racemic)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.