Description

3,4-Difluoro-6-Nitroanisole is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its unique substitution pattern, which makes it a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluoro and nitro groups contribute to biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Dye and Pigment Intermediate: Acts as a building block for synthesizing specialized fluorinated dyes and pigments.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	3,4-Difluoro-6-Nitroanisole
CAS No.	66684-64-8
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	1,2-Difluoro-4-methoxy-5-nitrobenzene; 4-Methoxy-3,4-difluoronitrobenzene; 6-Nitro-3,4-difluoroanisole; Benzene, 1,2-difluoro-4-methoxy-5-nitro-; 3,4-Difluoro-6-nitro-1-methoxybenzene
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-6-Nitroanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.