Description

2,3-Difluoro-6-Nitroanisole is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic positioning of fluorine and nitro substituents on the anisole scaffold, enabling precise molecular modifications. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a fluorinated building block for electronic chemicals used in display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the research and production of fluorinated electron-transport materials for high-efficiency displays.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes with unique colorfastness and spectral properties.

Basic Information

Item	Details
Product Name	2,3-Difluoro-6-Nitroanisole
CAS No.	66684-60-4
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	1,2-Difluoro-3-methoxy-4-nitrobenzene; 2,3-Difluoro-6-nitro-1-methoxybenzene; 3-Methoxy-2,6-difluoronitrobenzene; 6-Nitro-2,3-difluoroanisole; Benzene, 1,2-difluoro-3-methoxy-4-nitro-; Anisole, 2,3-difluoro-6-nitro-
EINECS	Contact for details

Quality Control

Every batch of our 2,3-Difluoro-6-Nitroanisole is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards, and comprehensive analytical testing is performed to guarantee identity, purity, and consistency. A Certificate of Analysis (COA) detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and tendency to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Single impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.