Description

1H-Imidazole, 2-(Trifluoromethyl)- is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the trifluoromethyl group attached to the imidazole ring, making it a critical intermediate for developing novel compounds with enhanced biological activity and material properties. This high-purity intermediate is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the CF3 group can improve metabolic stability and lipophilicity.
• Ligand and Catalyst Development: Serves as a precursor for N-heterocyclic carbene (NHC) ligands and other organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers, ionic liquids, and advanced organic electronic materials.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	1H-Imidazole, 2-(Trifluoromethyl)-
CAS No.	66675-22-7
Molecular Formula	C4H3F3N2
Molecular Weight	136.08 g/mol
Synonyms	2-(Trifluoromethyl)imidazole; 2-(Trifluoromethyl)-1H-imidazole; α,α,α-Trifluoro-2-imidazolemethane; 2-Trifluoromethylimidazole; 2-CF3-Imidazole; 2-Trifluoromethyl-1H-imidazole; 1H-Imidazole, 2-(trifluoromethyl)-; 66675-22-7
EINECS	Contact for details

Quality Control

Our 1H-Imidazole, 2-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.