Description

Boc-Tyr(Bzl)-Ol is a protected tyrosine derivative, specifically the benzyl ether of Boc-Tyrosine, widely used as a crucial building block in peptide synthesis. This compound is essential for researchers and manufacturers who require precise control over side-chain reactivity during the construction of complex peptide sequences. It is primarily utilized in pharmaceutical R&D and the production of active pharmaceutical ingredients (APIs) where high-purity intermediates are non-negotiable.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of tyrosine residues with protected phenolic hydroxyl groups.
• Solution-Phase Peptide Synthesis: Used in the synthesis of longer or more complex peptide chains in solution.
• Pharmaceutical Research: Serves as a critical raw material in the development of peptide-based therapeutics, hormones, and diagnostic agents.
• Bioconjugation: Acts as a precursor for creating tyrosine-containing linkers or tags for protein and antibody-drug conjugate (ADC) development.
• Chemical Biology Studies: Employed in the synthesis of peptide probes and tools for studying enzyme-substrate interactions and cellular processes.
• Custom Peptide Manufacturing: A standard reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke peptides for clients.

Basic Information

Product Name	Boc-Tyr(Bzl)-Ol
CAS No.	66605-58-1
Molecular Formula	C₂₁H₂₅NO₅
Molecular Weight	371.43 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-benzyl-L-tyrosine; Boc-O-Benzyl-L-tyrosine; Boc-Tyr(Bzl)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylmethoxyphenyl)propanoic acid; tert-Butyloxycarbonyl-O-benzyl-L-tyrosine; Boc-L-Tyrosine(Bzl)-OH; Boc-O-Bzl-L-Tyr-OH; N-Boc-O-benzyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our Boc-Tyr(Bzl)-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.