Description

n-Boc-L-Phenylalaninol CAS NO 66605-57-0 is a protected amino alcohol derivative, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile, optically pure scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This high-purity intermediate is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality raw materials for peptide mimetics, active pharmaceutical ingredients (APIs), and other fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Peptidomimetics Construction: Used to introduce the phenylalanine side chain with a protected amine and a hydroxymethyl handle for further functionalization.
• API Development: Serves as a building block in the research and scale-up production of new active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Employed in the preparation of chiral catalysts, ligands, and auxiliaries for stereoselective reactions.
• Agrochemical Research: Utilized in the development of novel herbicides, fungicides, and insecticides that require specific chiral architectures.
• Bioconjugation & Linker Chemistry: The hydroxyl and protected amine groups allow for conjugation to other molecules, useful in prodrug design and bioconjugate preparation.

Basic Information

Product Name	n-Boc-L-Phenylalaninol
CAS No.	66605-57-0
Molecular Formula	C₁₄H₂₁NO₃
Molecular Weight	251.32 g/mol
Synonyms	(2S)-3-Phenyl-2-[(tert-butoxycarbonyl)amino]-1-propanol; (S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropan-1-ol; Boc-L-Phenylalaninol; N-(tert-Butoxycarbonyl)-L-phenylalaninol; L-Phenylalaninol, N-Boc-; tert-Butyl (1S)-1-(hydroxymethyl)-2-phenylethylcarbamate; BOC-Phe-ol; (S)-2-(Boc-amino)-3-phenyl-1-propanol
EINECS	Contact for details

Quality Control

Our n-Boc-L-Phenylalaninol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards, and our quality commitment supports applications in cGMP pharmaceutical development and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under dry conditions to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.