Description

Imp. D (Ep) As Chloride: 1,3-Bis[(Biphenyl-4-Yl)-Phenylmethyl]-1H-Imidazolium Chloride is a high-purity, specialized ionic liquid and pharmaceutical intermediate of significant commercial and research importance. This compound is valued for its role as a key impurity standard and precursor in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, analytical laboratories, and R&D facilities focused on process chemistry and quality control for critical drug substances.

Application

• Pharmaceutical Impurity Standard: Serves as a certified reference material (CRM) for the identification and quantification of Impurity D in specific drug substances, ensuring compliance with pharmacopeial monographs (e.g., EP, USP).
• Advanced Material Synthesis: Acts as a precursor or catalyst component in the production of specialized ionic liquids, which are used in green chemistry, electrochemistry, and as advanced solvents.
• Process Chemistry Research: Utilized in method development and validation studies within pharmaceutical R&D to understand and control synthetic pathways.
• Analytical Method Development: Employed by QC/QA laboratories to develop and calibrate chromatographic methods (HPLC, LC-MS) for impurity profiling.
• Chemical Intermediate: Functions as a building block in organic synthesis for creating complex molecules with specific electronic or steric properties.

Basic Information

Product Name	Imp. D (Ep) As Chloride: 1,3-Bis[(Biphenyl-4-Yl)-Phenylmethyl]-1H-Imidazolium Chloride
CAS No.	66600-13-3
Molecular Formula	C46H36ClN2
Molecular Weight	651.24 g/mol
Synonyms	1,3-Bis[(1,1'-Biphenyl-4-yl)phenylmethyl]-1H-imidazolium Chloride; 1,3-Bis(4,4'-Diphenylbenzyl)imidazolium Chloride; Imidazolium, 1,3-bis[(1,1'-biphenyl-4-yl)phenylmethyl]-, chloride (1:1); Impurity D Chloride (EP); 1H-Imidazolium, 1,3-bis[(1,1'-biphenyl-4-yl)phenylmethyl]-, chloride; Tris(4-biphenylyl)methylimidazolium Chloride (common name); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our Imp. D (Ep) As Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation (IR, NMR), and specific impurity profiling, to ensure it meets stringent specifications for use as a reference standard. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.