Description

Propanenitrile, 3-(4-Pyridinyldithio)- (9Ci) CAS NO 66592-90-3 is a specialized bifunctional organic compound featuring both a nitrile group and a pyridyl disulfide moiety. This unique structure makes it a valuable heterobifunctional crosslinking agent and a key intermediate in bioconjugation chemistry for creating stable, cleavable linkages. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors. The compound is essential for developing advanced drug delivery systems, diagnostic reagents, and modified biomolecules.

Application

• Bioconjugation Reagent: A critical heterobifunctional crosslinker for covalently attaching proteins, peptides, or antibodies to other molecules, surfaces, or nanoparticles via its reactive disulfide and nitrile groups.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of prodrugs and targeted therapeutics where a controlled, reducible (disulfide) linkage is required for drug release.
• Polymer Modification: Used to introduce pyridyl disulfide groups into polymer backbones, enabling the subsequent attachment of thiol-containing ligands or biomolecules for smart material design.
• Surface Functionalization: Employed to create reactive self-assembled monolayers (SAMs) on gold or other surfaces for biosensor development and microarray platforms.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the development of cleavable linkers in ADCs, connecting cytotoxic payloads to monoclonal antibodies for targeted cancer therapy.
• Proteomics and Protein Labeling: Enables site-specific labeling and immobilization of proteins for activity studies, purification, and analytical applications.

Basic Information

Product Name	Propanenitrile, 3-(4-Pyridinyldithio)- (9Ci)
CAS No.	66592-90-3
Molecular Formula	C8H8N2S2
Molecular Weight	196.29 g/mol
Synonyms	3-(4-Pyridinyldithio)propiononitrile; 3-(Pyridin-4-yldisulfanyl)propanenitrile; 4-Pyridyl disulfide propiononitrile; PDP; 3-(4-Pyridyldithio)propionitrile; S-(4-Pyridyl) 3-cyanopropyl disulfide; 3-(4-Pyridyldisulfanyl)propionitrile; 4-PDS-propionitrile
EINECS	Contact for details

Quality Control

We supply Propanenitrile, 3-(4-Pyridinyldithio)- in high-purity grades suitable for research and bioconjugation applications. Our products undergo rigorous quality testing, including HPLC and NMR analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical data is provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.