Description

Adenosine, [2,8-3H] is a high-specific-activity tritium-labeled nucleoside essential for advanced biochemical and pharmacological research. This radiolabeled compound serves as a critical tracer for studying adenosine receptor binding, nucleotide metabolism, and signal transduction pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers in the fields of cardiology, neurology, and oncology for precise in vitro and in vivo studies.

Application

• Receptor Binding Assays: Quantitative analysis of adenosine A1, A2A, A2B, and A3 receptor affinity and density.
• Metabolic Pathway Tracing: Investigation of adenosine kinase and adenosine deaminase activity, and purine salvage pathways.
• Pharmacokinetic Studies: Tracking the absorption, distribution, metabolism, and excretion (ADME) of adenosine and related analogs.
• Cardiovascular Research: Studies on coronary blood flow, ischemic preconditioning, and anti-arrhythmic mechanisms.
• Neurological Research: Exploration of adenosine's role as a neuromodulator in sleep regulation, neuroprotection, and seizure activity.
• Diagnostic Probe Development: Serving as a precursor for synthesizing labeled probes for imaging and diagnostic applications.

Basic Information

Product Name	Adenosine, [2,8-3H]
CAS No.	66592-84-5
Molecular Formula	C10H13N5O4 (³H labeled)
Molecular Weight	Contact for details
Synonyms	9-β-D-Ribofuranosyladenine, [2,8-³H]; Tritiated Adenosine; Adenosine-2,8-³H; ³H-Adenosine; [2,8-³H]-Adenosine; Adenosine (tritium labeled); 6-Amino-9-β-D-ribofuranosyl-9H-purine, [2,8-³H]
EINECS	Contact for details

Quality Control

Every batch of Adenosine, [2,8-3H] is manufactured and analyzed under strict quality systems to ensure radiochemical purity and specific activity meet exacting research standards. Comprehensive testing includes HPLC analysis for chemical and radiochemical purity, and specific activity determination by liquid scintillation counting. A detailed Certificate of Analysis (COA), documenting batch-specific data, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as supplied. Due to its nature as an easily oxidized (store under inert atmosphere) and strictly light-sensitive (protect from all light exposure) material, prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and specific activity.

Specification

Item	Specification
Appearance	Clear solution
Identification (HPLC)	Conforms
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	20-40 Ci/mmol
Solvent	Ethanol:Water (9:1 v/v)
Concentration	1 mCi/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.