Description

5-Desmethyl-6-Methyl Glipizide is a key pharmaceutical intermediate and metabolite of the widely used antidiabetic drug Glipizide. This compound is of significant value in research and development for the synthesis of novel therapeutic agents and for conducting detailed metabolic studies. It serves as a critical building block for pharmaceutical chemists and researchers focused on diabetes treatment and drug metabolism. The high-purity material is essential for ensuring the accuracy and reliability of analytical and synthetic work in advanced pharmaceutical applications.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis and research of Glipizide analogs and next-generation sulfonylurea antidiabetic agents.
• Metabolite Reference Standard: Critical for use as a certified reference material (CRM) in bioanalytical method development and validation for pharmacokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Employed in in vitro and in vivo studies to understand the metabolic pathways and clearance mechanisms of Glipizide.
• Analytical Chemistry: Used as a high-purity standard for HPLC, LC-MS, and other chromatographic techniques in quality control laboratories.
• Biochemical Research: Investigation of the structure-activity relationship (SAR) of sulfonylurea compounds and their interaction with pancreatic β-cell receptors.
• Impurity Profiling: Serves as a known impurity or degradation product standard for the stability testing and specification setting of Glipizide API and finished dosage forms.

Basic Information

Product Name	5-Desmethyl-6-Methyl Glipizide
CAS No.	66375-96-0
Molecular Formula	C20H27N5O4S
Molecular Weight	433.53 g/mol
Synonyms	1-Cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea; 5-Desmethyl-6-methyl Glipizide; Glipizide Impurity F; Glipizide Metabolite M1; N-[[4-[([[Cyclohexylamino)carbonyl]amino)sulfonyl]phenyl]ethyl]-5-methylpyrazinecarboxamide; 5-Desmethyl-6-methyl-Glipizide; 5-Desmethyl-6-methylglipizide
EINECS	Contact for details

Quality Control

Our 5-Desmethyl-6-Methyl Glipizide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.