Description

Propranolol Glucuronide Sodium Salt is a key metabolite and analytical reference standard of the widely used β-blocker, propranolol. This high-purity compound is essential for accurate pharmacokinetic and metabolic studies, providing critical insights into drug disposition and clearance pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of diagnostic kits for bioanalytical method development and validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification of propranolol and its metabolites in biological matrices (plasma, urine) using HPLC, LC-MS, or GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the glucuronidation pathway, metabolic stability, and excretion profiles of propranolol.
• Bioanalytical Method Development: Used to validate assay specificity, accuracy, and precision in clinical and preclinical studies.
• Impurity Profiling: Employed as a known impurity or degradation product standard in the quality control of propranolol active pharmaceutical ingredient (API) and finished dosage forms.
• Enzyme Activity Assays: Acts as a substrate or reference compound for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Toxicological Research: Used in studies examining the role of drug metabolites in efficacy and safety profiles.

Basic Information

Product Name	Propranolol Glucuronide Sodium Salt
CAS No.	66322-66-5
Molecular Formula	C22H34NNaO8 • xH2O
Molecular Weight	463.50 g/mol (Anhydrous)
Synonyms	1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol Glucuronide Sodium Salt; Propranolol O-Glucuronide Sodium Salt; Propranolol 1-O-β-D-Glucuronide Sodium Salt; Sodium (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-((1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-yl)oxy)ethoxy)tetrahydro-2H-pyran-2-carboxylate; Propranolol β-D-Glucuronide Sodium Salt; Propranolol Glucuronide Na Salt
EINECS	Contact for details

Quality Control

Our Propranolol Glucuronide Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be aligned with common pharmacopeial requirements for reference standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.