Description

Cefotiam Hydrochloride CAS NO 66309-69-1 is a second-generation cephalosporin antibiotic in its hydrochloride salt form, offering enhanced stability and solubility for pharmaceutical manufacturing. This compound is valued for its broad-spectrum antibacterial activity, particularly effective against both gram-positive and gram-negative pathogens. It is a critical active pharmaceutical ingredient (API) primarily required by manufacturers in the pharmaceutical industry for the formulation of injectable antibiotic preparations.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the manufacture of injectable antibiotic formulations.
• Formulation of sterile powders for injection, intended for the treatment of serious bacterial infections.
• Used in clinical and hospital settings for infections of the respiratory tract, urinary tract, and surgical site infections.
• Research and development of new antibiotic combinations and delivery systems.
• Reference standard in analytical laboratories for quality control and method validation.
• Intermediate in the synthesis of more complex cephalosporin derivatives.

Basic Information

Product Name	Cefotiam Hydrochloride
CAS No.	66309-69-1
Molecular Formula	C18H23N9O4S3•HCl
Molecular Weight	598.10 g/mol
Synonyms	Cefotiam HCl; (6R,7R)-7-[[(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride; CGP 14221/E; Halospor; Pansporin; Spizef; T-2525; Ceradon
EINECS	Contact for details

Quality Control

Our Cefotiam Hydrochloride is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) are provided with each batch, detailing parameters such as assay, impurities, and identification. We can support compliance with relevant pharmacopeial standards (e.g., USP, EP, JP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Specific Optical Rotation	+60° to +70° (c=1, in water)
pH (1% aqueous solution)	3.0 - 5.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.