Description

2-Iodo-6-Methoxy-Benzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both an iodine substituent and a methoxy group ortho to the nitrile, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. It serves as a key intermediate in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen for further functionalization.
• Material Science Research: Serves as a monomer or precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Sonogashira, Heck) to form new carbon-carbon bonds.
• Ligand and Catalyst Development: The nitrile and methoxy groups can be modified to create novel chelating ligands for metal catalysts.
• Chemical Biology Probes: Used in the synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	2-Iodo-6-Methoxy-Benzonitrile
CAS No.	66195-38-8
Molecular Formula	C8H6INO
Molecular Weight	259.05 g/mol
Synonyms	6-Methoxy-2-iodobenzonitrile; 2-Iodo-6-methoxybenzonitrile; 2-Cyano-3-iodoanisole; Benzonitrile, 2-iodo-6-methoxy-; 3-Iodo-2-methoxybenzonitrile (isomer reference); 2-Iodo-6-methoxy-phenyl cyanide
EINECS	Contact for details

Quality Control

Our 2-Iodo-6-Methoxy-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and protect from prolonged exposure to light due to its light-sensitive nature.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.