Description

(+)-cis-Anti-N2-Bpde-Dg CAS NO 66141-82-0 is a high-purity, stereochemically defined polycyclic aromatic hydrocarbon (PAH) metabolite, specifically a diol epoxide derivative of benzo[a]pyrene. This compound is of critical importance as a reference standard and active metabolite in toxicological and carcinogenicity research. It is primarily needed by research institutions, pharmaceutical R&D departments, and analytical laboratories engaged in studies of DNA adduct formation, metabolic activation pathways, and environmental health risk assessment.

Application

• Biochemical Research Standard: Serves as an authentic reference material for the quantification and identification of DNA adducts formed by benzo[a]pyrene metabolites.
• Toxicology Studies: Used in in vitro and in vivo models to investigate the mechanisms of PAH-induced carcinogenesis and mutagenesis.
• Analytical Method Development: Essential for calibrating and validating sensitive analytical techniques such as HPLC-MS/MS, GC-MS, and 32P-postlabeling assays.
• Environmental Health & Safety: Employed in studies assessing human exposure to environmental pollutants and the associated cancer risk.
• Pharmaceutical R&D: Used in screening and evaluating potential chemopreventive agents that inhibit the metabolic activation of procarcinogens.

Basic Information

Item	Detail
Product Name	(+)-cis-Anti-N2-Bpde-Dg
CAS No.	66141-82-0
Molecular Formula	C30H26O3
Molecular Weight	434.53 g/mol
Synonyms	(+)-anti-7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; (+)-anti-BPDE; (+)-anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; anti-BPDE-dG adduct; 7R,8S,9S,10R-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; B[a]PDE; BPDE-N2-dG
EINECS	Contact for details

Quality Control

Every batch of (+)-cis-Anti-N2-Bpde-Dg is manufactured and analyzed under strict quality protocols to ensure identity, purity, and stability for research applications. Our quality assurance includes comprehensive analytical characterization using techniques such as NMR, HPLC, and MS. A Certificate of Analysis (COA) detailing batch-specific purity, chromatographic data, and storage recommendations is provided with each shipment to guarantee traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and light-sensitive nature, the material should be handled in a controlled environment with minimal exposure to air and moisture. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.