Description

Technetium Tc 99M (Sn)Methylenediphosphonate is a sterile, non-pyrogenic diagnostic radiopharmaceutical agent used for bone scintigraphy. Its core value lies in its ability to selectively localize in areas of altered osteogenic activity, providing critical diagnostic imaging for skeletal pathologies. This product is essential for nuclear medicine departments, diagnostic imaging centers, and research institutions specializing in oncology, orthopedics, and metabolic bone disease management.

Application

• Bone Scintigraphy (Bone Scan): Primary diagnostic tool for detecting bone metastases from cancers such as breast, prostate, and lung cancer.
• Evaluation of Benign Bone Disorders: Diagnosis and assessment of conditions like osteomyelitis (bone infection), Paget's disease, and traumatic injuries including stress fractures.
• Orthopedic Imaging: Pre-surgical planning and post-surgical evaluation of joint prostheses for potential loosening or infection.
• Oncologic Staging and Monitoring: Determining the extent (stage) of skeletal involvement in cancer and monitoring response to therapy.
• Metabolic Bone Disease Assessment: Aiding in the evaluation of disorders affecting bone turnover and mineralization.
• Research & Development: Used in preclinical and clinical research for developing new diagnostic protocols and studying bone physiology.

Basic Information

Product Name	Technetium Tc 99M (Sn)Methylenediphosphonate
CAS No.	66138-58-7
Molecular Formula	C2H6O7P2Sn • 99mTc
Molecular Weight	Contact for details
Synonyms	Technetium-99m MDP; 99mTc-MDP; MDP Kit (Stannous); Technetium Tc 99m Medronate; Methylenediphosphonic Acid, Technetium Tc 99m Complex; Bone Scan Agent; Methylene Diphosphonate Tc-99m; Osteolite™ (Trade Name); Medronate Kit for Technetium Tc 99m
EINECS	Contact for details

Quality Control

Every batch of Technetium Tc 99M (Sn)Methylenediphosphonate is manufactured and tested under strict aseptic conditions in compliance with current Good Manufacturing Practices (cGMP) for pharmaceuticals. Quality assurance includes rigorous testing for radiochemical purity, radionuclidic purity, sterility, apyrogenicity, pH, and tin content. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all release specifications.

Storage

Preserve the kit in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The final prepared radiopharmaceutical must be used within the time frame specified in the official product literature, adhering to radiation safety protocols. Store in accordance with local regulations for radioactive materials.

Specification

Item	Specification
Appearance	Sterile, non-pyrogenic kit components
pH (Reconstituted Solution)	4.0 - 7.0
Radiochemical Purity (HPLC/TLC)	≥ 90%
Radionuclidic Purity (Gamma Spectroscopy)	≥ 99.9% 99mTc
Sterility Test (Membrane Filtration)	Sterile
Bacterial Endotoxins (LAL)	< 175 EU/Vial
Tin Content (Atomic Absorption)	0.05 - 0.30 mg/vial
Identification (Gamma Ray Spectrum)	Complies

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.