Description

3',4'-Dihydroxyflurbiprofen is a key hydroxylated metabolite of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen. This compound is of significant interest in pharmaceutical research and development, particularly for studying drug metabolism and pharmacokinetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in analytical method development, metabolite identification, and preclinical studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of flurbiprofen and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Used as a critical metabolite standard to investigate the metabolic pathways, bioavailability, and clearance of flurbiprofen.
• Analytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for metabolite profiling in pharmacokinetic studies.
• Toxicology Research: Employed in studies assessing the safety and toxicity profile of flurbiprofen metabolites.
• Biochemical Research: Used as a tool compound to study the activity and role of specific cytochrome P450 enzymes involved in drug metabolism.
• Impurity Profiling: Acts as a known impurity standard for quality control in the manufacturing of flurbiprofen active pharmaceutical ingredient (API).

Basic Information

Product Name	3',4'-Dihydroxyflurbiprofen
CAS No.	66067-41-2
Molecular Formula	C15H13FO4
Molecular Weight	276.26 g/mol
Synonyms	2-(3-Fluoro-4-hydroxy-[1,1'-biphenyl]-4-yl)propanoic Acid; 2-(2-Fluoro-4-hydroxy-4'-hydroxybiphenyl-3-yl)propionic Acid; Flurbiprofen Metabolite III; 3'-Hydroxy-4'-hydroxyflurbiprofen; 4'-Hydroxy-3'-hydroxyflurbiprofen; 3',4'-DiOH-flurbiprofen; 1,1'-Biphenyl-3-propanoic acid, 3-fluoro-4,4'-dihydroxy-α-methyl-
EINECS	Contact for details

Quality Control

Our 3',4'-Dihydroxyflurbiprofen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.