Description

Ropivacaine-Et-Hcl CAS NO 66052-78-6 is a high-purity pharmaceutical intermediate and analytical reference standard, specifically the ethyl derivative of Ropivacaine hydrochloride. This compound is critical for research and development in the synthesis of novel long-acting local anesthetic agents. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and analytical service providers focused on developing and quality-testing next-generation anesthetic and pain management formulations.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of Ropivacaine analogs and related local anesthetic compounds.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC/QA) testing of Ropivacaine APIs and finished drug products in compliance with pharmacopeial standards (USP, EP).
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand the biotransformation of Ropivacaine.
• Impurity Profiling: Serves as a specified impurity or degradation product standard to ensure the purity and safety of the main active pharmaceutical ingredient (API).
• Preclinical Research: Used in pharmacological studies to investigate structure-activity relationships (SAR) for local anesthetics.
• Custom Synthesis: A starting material for the contract development and manufacturing (CDMO) of specialized anesthetic agents.

Basic Information

Product Name	Ropivacaine-Et-Hcl
CAS No.	66052-78-6
Molecular Formula	C18H29ClN2O
Molecular Weight	324.89 g/mol
Synonyms	(S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide Ethyl Derivative Hydrochloride; Ropivacaine Ethyl Impurity; Ropivacaine Related Compound E; 1-Propyl-2',6'-pipecoloxylidide Ethyl Derivative HCl; (S)-1-Propyl-2',6'-pipecoloxylidide Ethyl Analog Hydrochloride; Ropivacaine N-Ethyl Analog HCl; Local Anesthetic Intermediate
EINECS	Contact for details

Quality Control

Our Ropivacaine-Et-Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.