Description

Substance P, Sulfoxide is a chemically modified derivative of the neuropeptide Substance P, where a key methionine residue has been oxidized to its sulfoxide form. This modification is critical for studying the structure-activity relationships and oxidative stability of neuropeptides in biological systems. It serves as a valuable reference standard and research tool for neuroscientists and pharmaceutical developers investigating pain pathways, neuroinflammation, and receptor interactions. This high-purity compound is essential for advanced biochemical research and analytical method development in the life sciences.

Application

• Neuroscience Research: Used as a reference standard in studies of neurokinin-1 (NK1) receptor binding, activation, and signaling pathways.
• Analytical Chemistry: Serves as a critical standard for HPLC, LC-MS, and other chromatographic methods to identify and quantify Substance P and its metabolites.
• Pharmaceutical Development: Employed in stability studies to understand the oxidative degradation profile of peptide-based drug candidates.
• Biochemical Assays: Utilized in enzyme-linked immunosorbent assays (ELISAs) and radioimmunoassays (RIAs) for antibody validation and assay calibration.
• Academic Research: A key reagent for investigating the role of Substance P in pain transmission, migraine, emesis, and inflammatory processes.
• Peptide Chemistry Studies: Acts as a model compound for researching methionine oxidation and its impact on peptide conformation and biological activity.

Basic Information

Product Name	Substance P, Sulfoxide
CAS No.	66013-34-1
Molecular Formula	C63H98N18O14S2
Molecular Weight	1347.7 g/mol
Synonyms	Substance P Sulfoxide; [Met(O)11]-Substance P; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met(O)-NH2; Neurokinin P Sulfoxide; SP Sulfoxide; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met(O)-NH2; Methionine Sulfoxide-11-Substance P
EINECS	Contact for details

Quality Control

Our Substance P, Sulfoxide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the analytical results. We support compliance with relevant quality frameworks for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.