Description

α-Latrotoxin is a potent presynaptic neurotoxin isolated from the venom of widow spiders (genus Latrodectus). This high-purity biological toxin is a critical research tool for studying the mechanisms of neurotransmitter release, synaptic vesicle recycling, and exocytosis. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and diagnostic manufacturers for neurological research and assay development.

Application

• Neuroscience Research: A key reagent for investigating calcium-dependent and calcium-independent pathways of vesicular neurotransmitter release.
• Pharmacological Studies: Used to screen and evaluate compounds that modulate synaptic transmission and neurosecretion.
• Cell Biology & Physiology: Employed to probe the molecular machinery of exocytosis and membrane fusion in model cell systems.
• Diagnostic Development: Serves as a component in specialized assays and test kits for neurological targets.
• Toxin-Antitoxin Research: Used in the study of venom neutralization and the development of therapeutic antivenoms.

Basic Information

Product Name	α-Latrotoxin
CAS No.	65988-34-3
Molecular Formula	Contact for details
Molecular Weight	~130 kDa (Monomer)
Synonyms	α-Latrotoxin; α-LTX; Latrodectus tredecimguttatus α-Latrotoxin; Black Widow Spider Toxin α-Latrotoxin; Alpha Latroinsectotoxin; Neurotoxin α-Latrotoxin; LTX; α-Latrocrustatoxin
EINECS	Contact for details

Quality Control

Our α-Latrotoxin is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and safety data. We adhere to relevant Good Laboratory Practice (GLP) standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95%
Biological Activity (Cell-based assay)	≥ 1 x 10^7 units/mg
Endotoxin Level (LAL)	< 1.0 EU/μg
Protein Content (BCA)	≥ 90%
Solubility	Soluble in aqueous buffers
Residual Moisture (KF)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.