Description

Piperidine, 1-[(2S)-2-Pyrrolidinylcarbonyl]- (9Ci) is a specialized chiral piperidine derivative, a high-value building block in advanced organic synthesis. Its core value lies in its structural complexity, which makes it a critical intermediate for constructing sophisticated pharmacologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents. Its precise stereochemistry and functional groups enable the creation of novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for neurological and psychiatric disorders.
• Asymmetric Synthesis: Used as a building block in stereoselective synthesis to introduce the (S)-configured pyrrolidine-carbonyl-piperidine moiety into complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes within drug discovery programs.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands or organocatalysts used in enantioselective transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	Piperidine, 1-[(2S)-2-Pyrrolidinylcarbonyl]- (9Ci)
CAS No.	65921-40-6
Molecular Formula	C10H18N2O
Molecular Weight	182.26 g/mol
Synonyms	(S)-1-(Pyrrolidine-2-carbonyl)piperidine; 1-[(2S)-2-Pyrrolidinylcarbonyl]piperidine; (S)-N-(Piperidin-1-yl)pyrrolidine-2-carboxamide; L-Proline piperidide; (S)-Pyrrolidine-2-carboxylic acid piperidide; 65921-40-6; 1-(L-Prolinyl)piperidine
EINECS	Contact for details

Quality Control

Our Piperidine, 1-[(2S)-2-Pyrrolidinylcarbonyl]- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.