Description

3-Methylsulfonyloxypropanenitrile is a versatile chemical intermediate featuring a reactive mesylate (methylsulfonyloxy) group and a nitrile functionality. This dual reactivity makes it a valuable building block for the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists for constructing novel compounds and fine-tuning molecular properties. The compound, identified by CAS No. 65885-27-0, is a key reagent for introducing propanenitrile-derived chains into target structures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a functionalized nitrile or a protected alcohol equivalent.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the propanenitrile moiety is a critical structural component.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced materials.
• Organic Synthesis Building Block: Employed in nucleophilic substitution reactions (SN2) where the mesylate group is an excellent leaving group, facilitating carbon-chain elongation.
• Ligand and Catalyst Preparation: Useful for modifying complex molecules to create novel ligands for catalysis or diagnostic applications.
• Fine Chemical Production: Integral in multi-step synthesis processes for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	3-Methylsulfonyloxypropanenitrile
CAS No.	65885-27-0
Molecular Formula	C₄H₇NO₃S
Molecular Weight	149.17 g/mol
Synonyms	3-(Methylsulfonyloxy)propanenitrile; Propanenitrile, 3-[(methylsulfonyl)oxy]-; 3-Mesyloxypropionitrile; 3-(Methanesulfonyloxy)propionitrile; 3-Hydroxypropionitrile methanesulfonate; MSN; Mesyloxypropionitrile
EINECS	Contact for details

Quality Control

Our 3-Methylsulfonyloxypropanenitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography and spectroscopy, to verify identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.