Description

Beta(Sub 1)-Bungarotoxin is a highly specific, long-chain neurotoxin isolated from the venom of the Taiwanese banded krait (*Bungarus multicinctus*). This compound is a critical research tool for the selective and irreversible blockade of postsynaptic nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It is essential for researchers in neurobiology, pharmacology, and toxicology studying synaptic transmission, receptor characterization, and the development of neuromuscular agents.

Application

• Neuroscience Research: Selective inhibition of muscle-type nicotinic acetylcholine receptors (α1β1γδ) for studying synaptic physiology and plasticity.
• Pharmacological Studies: Used as a standard antagonist to characterize new cholinergic compounds and evaluate their receptor subtype specificity.
• Toxicology & Venom Research: A reference standard for analyzing krait venom composition and studying the mechanisms of neurotoxic envenomation.
• Drug Discovery: Target validation and screening in programs focused on neuromuscular disorders, myasthenia gravis, or muscle relaxants.
• Cell Biology: Tool for blocking nAChR function in cell culture models to investigate receptor trafficking and signaling pathways.
• Diagnostic Development: Potential use in assay development for detecting anti-nAChR antibodies relevant to autoimmune conditions.

Basic Information

Item	Details
Product Name	Beta(Sub 1)-Bungarotoxin
CAS No.	65862-89-7
Molecular Formula	C390H602N112O118S14 (Approximate, for major isoform)
Molecular Weight	~8,900 Da (Monomer)
Synonyms	β1-Bungarotoxin; β-1-Bungarotoxin; Bungarotoxin Beta1; Toxin Bm 9.2.1; β-Bungarotoxin Chain A; Presynaptic phospholipase A2 neurotoxin; Long-chain neurotoxin; Bungarus multicinctus venom toxin fraction 4
EINECS	Contact for details

Quality Control

Our Beta(Sub 1)-Bungarotoxin is produced and tested to meet the exacting standards of life science research. Each lot undergoes rigorous analysis to ensure high purity, specific biological activity, and consistency. Quality is verified by multiple orthogonal methods, including HPLC for purity and in vitro bioassay for functional activity. A comprehensive Certificate of Analysis (COA), detailing purity, potency, endotoxin levels, and analytical data, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C or below to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (Mouse phrenic nerve-hemidiaphragm assay)	Fully characterized, specific activity provided on COA
Protein Content (UV Absorbance)	≥ 90%
Endotoxin Level (LAL)	< 1.0 EU/μg
Solubility	Soluble in water or physiological buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.