Description

5-Chloro-8-Hydroxyquinoline Glucuronide is a key glucuronide conjugate metabolite of the bioactive quinoline derivative, 5-chloro-8-hydroxyquinoline. This compound matters for researchers and manufacturers as it serves as a critical reference standard for metabolic and pharmacokinetic studies, ensuring accurate analysis and quality control in drug development. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers involved in ADME (Absorption, Distribution, Metabolism, and Excretion) profiling and bioanalytical method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quantifying metabolites in biological matrices during preclinical and clinical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand the metabolic pathway and clearance mechanisms of 5-chloro-8-hydroxyquinoline.
• Bioanalytical Method Development: Serves as a critical standard for developing and validating sensitive HPLC-MS/MS or LC-UV methods for metabolite detection.
• Toxicology Studies: Employed to assess the safety profile and potential bioaccumulation of the parent compound's metabolites.
• Impurity Profiling: Used in the quality control of active pharmaceutical ingredients (APIs) to identify and quantify related substances and degradation products.
• Academic Research: Supports fundamental research in medicinal chemistry and biochemistry focusing on quinoline drug metabolism and glucuronidation processes.

Basic Information

Product Name	5-Chloro-8-Hydroxyquinoline Glucuronide
CAS No.	65851-39-0
Molecular Formula	C₁₅H₁₆ClNO₈
Molecular Weight	373.74 g/mol
Synonyms	5-Chloro-8-quinolinyl β-D-Glucopyranosiduronic Acid; 5-Chloro-8-hydroxyquinoline β-D-Glucuronide; 8-Hydroxy-5-chloroquinoline Glucuronide; Glucuronide of 5-Chloro-8-hydroxyquinoline; 5-Cl-8-HQ Gluc; 5-Chloro-8-HQ-Glucuronide; (5-Chloro-8-quinolyl)-β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-8-Hydroxyquinoline Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for reference materials. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.