Description

Ribonuclease S-Peptide is a defined proteolytic fragment of bovine pancreatic ribonuclease A, representing the N-terminal 1-20 residues. This peptide is critically important in structural biology and enzymology as it is essential for reconstituting the active site of the ribonuclease S complex when combined with the complementary S-protein. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in protein folding studies, enzyme mechanism analysis, and as a model system for protein-protein interactions.

Application

• Enzyme Research & Mechanism Studies: Used to study the reconstitution, folding, and catalytic mechanism of Ribonuclease A.
• Protein-Protein Interaction Model: Serves as a classic, well-defined model system for investigating non-covalent binding and complex formation.
• Biochemical Reagent: Employed in laboratory settings for the controlled cleavage of RNA, often in conjunction with S-protein.
• Structural Biology: A key component in X-ray crystallography and NMR studies to elucidate the three-dimensional structure of the RNase S complex.
• Teaching & Reference Standard: Used in advanced biochemistry courses and as a high-purity reference material for analytical methods.
• Peptide Synthesis & Modification Studies: Acts as a substrate or template for studying site-specific chemical modifications of peptides.

Basic Information

Product Name	Ribonuclease S-Peptide
CAS No.	65742-22-5
Molecular Formula	C94H155N39O31S2
Molecular Weight	~2166.6 g/mol
Synonyms	RNase S-Peptide; Ribonuclease A S-Peptide (1-20); S-Peptide (1-20); RNase A S-Peptide; H-Lys-Glu-Thr-Ala-Ala-Ala-Lys-Phe-Glu-Arg-Gln-His-Met-Asp-Ser-Ser-Thr-Ser-Ala-Ala-OH; Ribonuclease S Peptide Fragment 1-20; S-Protein Complementary Peptide
EINECS	Contact for details

Quality Control

Our Ribonuclease S-Peptide is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Sequence	KETAAAKFERQHMDSSTSA
Molecular Weight	2166.6 ± 2 Da
Water Content (KF)	≤ 5.0 %
Biological Activity (Reconstitution)	Fully active in reconstituting RNase S complex

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.